Abstract: Synthetic musk was widely used in daily consumer products such as cosmetics, and could be divided into three categories: nitro musk, macrocyclic musk, and polycyclic musk. But corresponding research has shown that it was potentially toxic to the human, and polluted the environment. The basic information, aroma characteristics and the applications of Versalide, Musk Moskene, Musk ambrette paste, Musk Tibetan and Xylene Musk was comprehensively introduced. The hazards and detection methods were described in detail. This may provide relevant information and detection methods for the safe application of synthetic musk in fragrance.