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基于卟啉的糖识别探针

Porphyrin-Based Fluorescent Sensors for Saccharides

  • 摘要: 糖是生命存在和繁衍所必需的物质,担负着为生物体提供碳源和能量的重担。发展能够对复杂生物体中特定糖类化合物进行定量分析检测的新技术、新方法具有重要的实际意义。卟啉是一类基于四吡咯芳香大环核心结构的化合物,具有化学性质稳定、摩尔消光系数大、荧光发射波长等优秀的化学和光物理性能,其应用于生物分析具有许多先天的优势。力求系统性地总结归纳以卟啉结构为基础的分子探针在糖识别领域的研究现状,并展望卟啉这一特殊荧光团在发展糖识别探针这一领域的发展前景。

     

    Abstract: Saccharides are essential for the activities of life systems by providing carbon resources and energy. Therefore, the innovation of quantitative analytical methods for sensing a target saccharide in a complicated biological sample is meaningful. Porphyrin is a family of aromatic compounds with a macrocyclic structure that built up with four pyrrolic subunits. In general, porphyrins are chemically stable and exhibit excellent photophysical properties such as large molar extinction coefficient and long emission wavelength, making them suitable for application in biological analysis. In this review, we tried to discuss the research progresses on porphyrin based molecular sensors for saccharide recognition. We hope that these discussions would inspire the further development of practical and convenient porphyrin-based sensors for detecting saccharides in real biological samples.

     

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