Abstract: As an important chemical material, bisphenol A (BPA) is a naturally refractory endecrine interfering substance, which will harm to organisms and human beings by the interference of natural hormone. Two CeO₂-based materials were prepared on the γ-Al₂O₃ monolithic spherical support with hydrothermal method and impregnation method. The structure, morphology, and composition of the CeO₂ were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), Raman spectroscopy (Raman) and specific surface area and pore size distribution analyzer (physical adsorption). The ability of CeO₂/γ-Al₂O₃ prepared by two methods to catalyze the degradation of BPA in water was investigated at room temperature and pressure. Results indicate that the supported catalysts prepared by the two methods have stable performance with low leaching rate and stable loading in degrading BPA. The total organic carbon (TOC) removal rate of wastewater can be increased from 32.34% of pure ozone oxidation to 84.31% of CeO₂/γ-Al₂O₃(Hyd) which is much higher than that of CeO₂/γ-Al₂O₃(Imp). The prepared monolithic catalyst of rare earth ozone oxidation has good industrial application prospect, since it solves the problem of difficult recovery of solid-phase catalysts while effectively improves the catalytic efficiency of supported catalysts.