Abstract: In order to effectively evaluate the comprehensive application effect of steel box girder bridge, a combined weighting evaluation model of variation coefficient and AHP was established, and the Grey Comprehensive Evaluation method was introduced to determine the effect grade. Taking an expressway in Henan province as an example, the AHP method was used for subjective weighting, and the measured value of the index was substituted into the coefficient of variation method to obtain the objective weight. The combined weight and grey evaluation method were integrated to determine the comprehensive grade of application effect of steel box girder bridge. The results show that the application effect grade of the example steel box girder bridge is “good”, which is consistent with the actual situation. The evaluation process and results of this method have sufficient reliability and validity, which can provide reference for the evaluation of similar projects.