微波与离子液体协同催化高效合成1,4-二氢吡啶类化合物

Efficient synthesis of 1,4-dihydropyridines catalyzed by microwave and ionic liquids

摘要: 在以吡啶为母体的离子液体和微波辐射协同催化下，以醋酸铵、间硝基苯甲醛和3-氧代-N-苯基丁酰胺为原料，通过Hantzsch反应一锅合成2,6-二甲基-4-3ˊ-硝基苯基-N³,N⁵-二苯基-3,5-二甲酰胺-1,4-二氢吡啶化合物，产物结构通过¹H-NMR表征进行了确认。与文献中描述的方法相比，该方法具有反应过程简单、反应时间短、收率高、催化剂易重复使用等优点。

Abstract: 2,6-dimethyl-4-3ˊ-nitrophenyl-N³,N⁵-diphenyl-3,5-diformamide dihydropyridine was synthesized from 3-nitrobenzaldehyde, 3-oxygen-N-phenylbutanamide and ammonium acetate via Hantzsch reaction in the presence of ionic liquid with pyridine as the mother under microwave irradiation. The corresponding structure of the product is characterized by ¹H-NMR. Compared by the methods in the literature, this method has a simple reaction process, short reaction time, high yield, and easy reuse.