6-异丙基-3,4-二氢嘧啶类化合物的高效催化合成

High efficiency catalytic synthesis of the 6-isopropyl-3,4-dihydropyrimidones

摘要: 开发了一种新型、简便的合成方法，在无溶剂条件下，以4,5-甲基-L-脯氨酸为催化剂，催化比吉内利反应（Biginelli reaction）高效合成6-异丙基-3,4-二氢嘧啶类化合物。反应条件温和，催化剂环保，产率优异（高达99%），可以获得广泛的具有显著生物活性的目标产物。

Abstract: A novel and simple catalytic methodology to highly efficient synthesis of the 6-isopropyl-3,4-dihydropyrimidines via Biginelli condensation using efficient, eco-friendly 4,5-methano-L-prolines as catalyst under solvent-free condition has been developed. A variety of compounds with excellent biological activity was obtained in good to excellent high yields (up to 99 %) under mild conditions.