Abstract: For the current frequent building fires in China, in order to analyze the influence of population psychological state in fire evacuation on evacuation, this study was used to determine the influencing factors of panic psychology in fire evacuation through the questionnaire survey. In the Anylogic software, based on the SIS (susceptible infected susceptible) classic infectious disease model, refine the population state, introduce the fire influence factor, and construct the dynamic model of panic under fire condition. Results said fire impact factor dominated in the evacuation, in the evacuation of various stages, the biggest influence in the early fire, the second guide the positive effect of evacuation, evacuation panic situation than panic evacuation efficiency reduced by about 27.03%, the initial stage will be in the state of panic, to the middle of the waiting area, and the closer to the center of the room, the more serious the crowd panic, the longer the duration.