Abstract: Lotus (Nelumbo) is an aquatic plant of global importance in ecology, landscaping, food, medicine, materials, and culture. Based on literature from the Web of Science Core Collection, this study used CiteSpace to analyze author collaborations, institutional networks, research trends, and hotspots in lotus studies over the past 25 years, providing insights for future research. Globally, English publications on lotus research have steadily increased, with China being the leading contributor. Establishing a dedicated journal for lotus research could help consolidate findings and highlight China's high-quality studies. Key research terms include Nelumbo, lotus leaf, lotus plumule, phylogeny, evolution, identification, flavonoids, alkaloids, and methylcorypalline. Studies on the antioxidant, anti-inflammatory, and lipid-lowering effects of lotus remain a major focus. Analysis of recent National Natural Science Foundation projects shows growing interest in the bioactive mechanisms of different lotus parts. This paper summarizes current research on lotus components' health benefits and explores future directions. Further innovations in food, medicine, and ornamental applications can be achieved through interdisciplinary approaches and integrating traditional and modern medicine.